10. pain pathway - substance p can cause edema and swelling...

Info icon This preview shows page 1. Sign up to view the full content.

This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: substance p can cause edema and swelling in the damaged are a C fibers (nociceptors) CGRP Substance P Histamine Damage Prostaglandin Bradykinin To CNS Nerve growth factor Site of injury Plasma Prostaglandin Bradykinin To CNS Initial spreading Plasma Prostaglandin Bradykinin To CNS Further spreading Plasma the pain thershold is much lower in an are a after it has be en previously nociceptors threshold to produce a painful activation becomes lower and e asier to excite as it gets more activated and sensitiz ed. E x. a burned are a is much more sensitive homosynaptic potentiation is associated with primary hyperalgesia (senstivity of the burned are a) while the heterosynaptic facilitation is associated with the spre ading sensitivity (secondary hyperalgesia) This deviation in the activated cortical are a is only present in ppl who have the phantom limb pain, not just ampute es the insular cortex is 23 on the diagram. action ...
View Full Document

  • Winter '16
  • Sean Mulligan
  • Histamine, insular cortex, Prostaglandin, hyperalgesia

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern