LEC08 - Clicker points 4 pts for each lecture this week to...

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Clicker points 4 pts for each lecture this week to make up for last Friday Fixing a bug in iClicker transfer to CCLE: no points posted for next week Midterm I: Lecture material Homework material Discussion sections Not responsible for material in text not covered
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Clicker question will be regraded: Credit for 1 or 2 H bonds
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Two types of topoisomerases Type I: relax supercoiled DNA without need for ATP Type II: require ATP to either relax supercoiled DNA or introduce supercoils (gyrase in bacteria)
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Type I: cuts one DNA strand (nick) Type II: cuts both DNA strands
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Type 1 Topoisomerase breaks one strand of the DNA, allows the DNA to unwind and then religates it
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Energy is retained in a new phosphodiester bond between the DNA and protein.
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Compounds that inhibit topoisomerases are used in chemotherapy Topoisomerase I inhibitors: Ironotecan, topotecan. Topoisomerase II inhibitors : Amsacrine, etoposide, etoposide phosphate, teniposide.
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Chromatin (eukaryotes)
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DNA in chromosomes is found complexed with protein This DNA/protein complex is called
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