LEC19 - 44 Human genome is composed of transposable...

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44% Human genome is composed of transposable elements
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Repression of transposable elements Inhibit transcription with DNA methylation and histone methylation (induce heterochromatin) Destroy RNA if synthesized siRNAs are found primarily to transposable elements piRNAs: germ cell specific
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RNAi: RNA interference siRNAs are made from double- stranded RNAs siRNAs can direct either RNA degradation in the cytoplasm or histone and DNA modifications in the nucleus
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piRNAs function primarily in germ cells to repress transposable elements They carry pieces of transposable elements and work similar to the CRISPR system in bacteria Also referred to as “transposon graveyards”
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DNA Replication
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DNA Replication (S phase) Cell Division (Mitosis)
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Mechanism proposed by Watson & Crick New strand Old strand Old strand
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Models for DNA replication (Meselson-Stahl, 1958) Conservative Semi-conservative
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Or dispersive dispersive
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How can one distinguish between the original strands of DNA and the newly synthesized strands?
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