Lecture 2 - Exam 1 - Friedrich Serturner 1803 isolating...

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Friedrich Serturner - 1803 isolating morphine First alkaloid chemist ever JJ Moreau (de Tours) Created Double Mescs - Hashish Club de Hashischins in the Hotel Pimodan (Got high in this club) Albert Niemann extracted cocaine Nagai Nagayoshi extracted amphetamines Albert Hofmann extracted LSD Birth of psychopharmacology Responsible for Discovery were Laborit, Charpentier, and Delay 1950's - Tranquilizers 1960's - Sedatives and anxiolytics Decrease in patients in mental hospitals following antipsychotic drug use 1970's - Endogenous receptors 1980's - Designer drugs and crack 1990's - Mood and personality pills (Prozac) 2000's - Pharmaco-genetics (Specific for your genotype) 2010's - Delivery systems Drug = substance with a biological action Determinants of biological action: o Drug receptors o Administration (how it is taken can affect the reaction) o Absorption (has to secrete from the stomach to the brain) o Distribution o Drug fate (how it is metabolized) o Dosage (no dangerous drug, just how much you take) o
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