Glycolysis & regulation FB (1)

Glycolysis & regulation FB (1) - GLYCOLYSIS GLYCOLYSIS...

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GLYCOLYSIS
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GLYCOLYSIS The term Glycolysis is derived form the Greek worlds Glykys meaning “sweet” Lysis meaning “Splitting”
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Major pathways of glucose utilization
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Overview of Glycolysis ONE 6-C glucose breaks into Two 3-C pyruvate Glycolysis involves 10-steps First 5 steps constitute Preparatory phase Last 5 steps constitute Payoff phase Three types of chemical transformation Degradation of glucose to pyruvate Phosphorylation of ADP to yield ATP Transformation of H atoms to NAD + yielding NADH
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The preparatory phase
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The payoff phase
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Fate of Pyruvate
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THE PREPARATORY PHASE
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Phosphorylation of Glucose 1 Hexokinase
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Phosphohexose isomerase Isomerization of glucose 6-phosphate 2
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Phosphofructokinase-I 3 Phosphorylation of fructose 6-phosphate
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Aldolase 4 Cleavage of fructose-1,6-bisphosphate
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Triose phosphate isomerase Cleavage of fructose-1,6-bisphosphate
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Triose phosphate isomerase 5 Isomerization of triose phosphate
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THE PAYOFF
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