Nucleophilic substitution day 1 - CHEM 2071-007 MACKENZIE...

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CHEM 2071-007 MACKENZIE WILLIAMSON 142 JUAN HU EXPERIMENT 6: UNIMOLECULAR AND BIMOLECULAR NUCLEOPHILIC SUBSTITUTION REACTIONS DAY 1
CONCLUSIONS Nucleophilic substitution reactions occur when a nucleophile attaches to an electrophile and a leaving group on the electrophile leaves and attaches to a new substance. There are two main types of nucleophilic substitution reactions that can occur; S N 2 and S N 1 reaction. The S and N letters represent nucleophilic substitution, but the different numbers tell how many steps are happening in each reaction. For S N 2 reactions, a bond is broken and a new bond is formed in one step. For S N 1, reactions happen with one step occurring at a time. Another way to think about whether a reaction will be S N 1 or S N 2 is to think about the reaction rate equation. For S N 1 reactions, only the substrate and the nucleophile affect the rate of the reaction. On day one of this lab we synthesize t-amyl Chloride (2-chloro-2-methylbutane). This mechanism ends up being S N 1. This is a three step mechanism. First the acid (HCl) protonates the alcohol to form a good

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