Lecture 2 September 4

Lecture 2 September 4 - Membrane transport and signaling 1...

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9/4/15: Membrane transport and signaling 1. Plasma Membrane Review a. Phospholipid bilayer i. Trans-membrane proteins ii. Some carbs, cholesterol and glycolipids iii. Fluid mosaic model: reflects the allowable movement of proteins within the phospholipid bilayer b. Polarity: any molecule carrying charge or having an unequal distribution of electrons (like dissolves like) i. Water, ions, carbs ii. Polar: hydrophilic, lipophobic iii. Non-polar: hydrophobic, lipophilic iv. Phospholipids -Polar, hydrophilic head, nonpolar, hydrophobic tail c. Membranes restrict movement i. Permeability: membranes are selectively permeable -Completely permeable to nonpolar molecules O2, CO2, lipids -Selectively permeable to polar molecules Ions, water, most proteins ii. Getting across the plasma membrane -Unassisted transport: with concentration gradient only Simple diffusion: substances diffuse freely across the membrane from greater to lesser concentration, nonpolar molecules Rate depends on solubility, surface area and
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