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Biol 460 Test _ 4 Part 2

Biol 460 Test _ 4 Part 2 - I Filaroviridae(filamentous Chap...

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I. Filaroviridae (filamentous) Chap. 30 p. 484 a. General properties (1) morphology -Long pleomorphic viruses - filamentous or convoluted forms - See Fig. 30-1 p. 485. -80nm diam; length 0.5-14um (particles as long as 14,000nm seen). -linear ssRNA single molecule; helical symmetry with envelope. (2) viral replication -7 proteins in genome - See Fig. 30-2 p. 486. -viruses multiply in cytoplasm, forming large inclusion bodies from aggragated nucleocapsids. -bud from plasma membrane. b. Pathogenesis and clinical features -Two important human pathogens (1) Marburg Virus - 25% fatality (2) Ebola Virus - 4 strains Ebola-Zaire or Z - 90% mortality Ebola-Sudan or S - 60% mortality Ebola-Reston strain (in monkeys) - humans only get subclinical disease; no mortality Ebola-Ivory Coast - no mortality -these filoviruses cause the most severe of the hemorrhagic fevers with the highest fatality rates even though they are not arboviral. -Found in Africa - rare. - Clinical symptoms similar to arbovirus hemorrhagic fevers. Very rare and pathogenic - Class 4 pathogens - must be handled at maximum security containment units (CDC) -Rapid onset with fever, diarrhea, severe hemorrhages, vomiting, abdominal pain, myalgia, pharyngitis, conjunctivitis and proteinuria. c. Lab diagnosis -*Class 4 pathogen (P4). Specimens must be taken with great care and shipped to one of only 6 P4 facilities. See Fig. 32-3 p. 503 - at CDC -Isolated on Vero cells (monkey kidney cells) and identified by EM. -Infected cultures can be gamma irradiation sterilized and stained with FAB. -Patients serum tested for Ab to virus using virus-infected Vero cells sterilized by gamma irrad. (FAB or RIA) d. Epidemiology, prevention and control
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