Biol 460 Test _ 4 Part 2

Biol 460 Test _ 4 Part 2 - I. Filaroviridae (filamentous)...

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I. Filaroviridae (filamentous) Chap. 30 p. 484 a. General properties (1) morphology -Long pleomorphic viruses - filamentous or convoluted forms - See Fig. 30-1 p. 485. -80nm diam; length 0.5-14um (particles as long as 14,000nm seen). -linear ssRNA single molecule; helical symmetry with envelope. (2) viral replication -7 proteins in genome - See Fig. 30-2 p. 486. -viruses multiply in cytoplasm, forming large inclusion bodies from aggragated nucleocapsids. -bud from plasma membrane. b. Pathogenesis and clinical features -Two important human pathogens (1) Marburg Virus - 25% fatality (2) Ebola Virus - 4 strains Ebola-Zaire or Z - 90% mortality Ebola-Sudan or S - 60% mortality Ebola-Reston strain (in monkeys) - humans only get subclinical disease; no mortality Ebola-Ivory Coast - no mortality -these filoviruses cause the most severe of the hemorrhagic fevers with the highest fatality rates even though they are not arboviral. -Found in Africa - rare. - Clinical symptoms similar to arbovirus hemorrhagic fevers. Very rare and pathogenic - Class 4 pathogens - must be handled at maximum security containment units (CDC) -Rapid onset with fever, diarrhea, severe hemorrhages, vomiting, abdominal pain, myalgia, pharyngitis, conjunctivitis and proteinuria. c. Lab diagnosis -*Class 4 pathogen (P4). Specimens must be taken with great care and shipped to one of only 6 P4 facilities. See Fig. 32-3 p. 503 - at CDC -Isolated on Vero cells (monkey kidney cells) and identified by EM. -Infected cultures can be gamma irradiation sterilized and stained with FAB. -Patients serum tested for Ab to virus using virus-infected Vero cells sterilized by gamma irrad. (FAB or RIA) d. Epidemiology, prevention and control
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Ebola Hemorrhagic Fever Table Showing Known Cases and Outbreaks, in Chronological Order Year Ebola subtype Country No. cases % Mortality 1976 Ebola-Zaire Zaire [Congo (DRC)] 318 88% 1976 Ebola-Sudan Sudan 284 53% 1976 Ebola-Sudan England 1 0% 1977 Ebola-Zaire Zaire 1 100% 1979 Ebola-Sudan Sudan 34 65% 1989 Ebola-Reston USA 0 0% 1990 Ebola-Reston USA 0 0% 1992 Ebola-Reston Italy 0 0% 1994 Ebola-Zaire Gabon 49 59% 1994 Ebola-Ivory Coast Ivory Coast 1 0% 1995 Ebola-Zaire Democratic 315 81% Republic of the Congo (formerly Zaire) 1996 Ebola-Zaire Gabon 31 68% 1996 Ebola-Zaire Gabon 60 75% 1996 Ebola-Zaire South Africa 2 50% 1996 Ebola-Reston USA 0 0% 1996 Ebola-Reston Philippines 0 0% 2000- Ebola- Uganda 425 53% 2001 Sudan 2001- Ebola-Zaire Gabon and The 122 79% 2002 Republic of the Congo
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J. Arenaviridae (Sand) Chapter 32 p. 500 a. General properties (1) Morphology -helical symmetry with envelope - pleomorphic -2 segments of ambisense (some + and some-) circular ssRNA in gneome (complementary H bonding at ends forms circles) -one of segments is small (S segment -3.4kb), and one is large ( L segment -7.2kb). -Each of the 2 circular segments has a separate helical nucleocapsid and both are enclosed in a
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This note was uploaded on 04/21/2008 for the course BIOL 101 taught by Professor Kilgen during the Spring '08 term at Nicholls State.

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Biol 460 Test _ 4 Part 2 - I. Filaroviridae (filamentous)...

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