Digestive System III with px

Digestive System III with px - Digestive System III: Liver,...

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Digestive System III: Liver, Gallbladder, and Pancreas : Chapter 18, pages 576 – 611. I. General features A. Components of the system 1. Pancreas, liver – digestive glands 2. Gall bladder – stores bile B. Embryonic origin – each component is out-pocketing of gut tube; duct. Duct- lining cells and exocrine secretory cells – endodermal; CT capsules – mesoderm. C. Exocrine and endocrine functions D. Serous and mucous exocrine secretory cells: liver, pancreas II. Liver: largest gland of the body; 4 lobes A. General structure 1. Tunica serosa or capsule of Glisson –septa divide liver into lobes and lobules 2. Porta hepatis: the transverse fissure located on inferior surface of liver. The hepatic portal vein, hepatic artery, and hepatic bile duct enter/exit liver. B. Blood supply: liver is organized around blood supply 1. Hepatic portal vein: oxygen-poor, nutrient-rich; also by-products of RBC destruction. Branch into portal venules and into sinusoids. Supplies 75% blood volume. 2. Hepatic artery: oxygen-rich, nutrient-poor. Branching into sinusoids; supplies 25% blood volume
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3. Sinusoids: liver blood capillaries; lie b/w radially oriented hepatocyte plates; receives arterial and venous blood from hepatic portal v. and hepatic a. a. Endothelial cells: discontinuous endothelial wall, typical endothelial cells b. Space of Disse: b/w hepatocytes and endothelium; blood plasma enters to contact microvilli of hepatocytes
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c. Lymphatics: space of Disse serve as lymphatics with flow opposite that of blood 4. Central veins: receive blood from sinusoids; located in center of liver lobule 5. Hepatic veins: oxygen-poor, nutrient poor blood; merging of sublobular veins; enter into inferior vena cava C. Cell Types: figure 18.12, page 587 1. Hepatocytes: structural and functional subunit
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a. Structure and organization: one or 2 nuclei; all organelles; glycogen granules and lipid droplets; polygonal cells with 6 sides – cubelike. Cells organized in one or 2 cell plates. Bile canaliculi (small membrane-bound tubular gaps
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This note was uploaded on 04/21/2008 for the course BIOL 101 taught by Professor Kilgen during the Spring '08 term at Nicholls State.

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Digestive System III with px - Digestive System III: Liver,...

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