Exam 1 endocrinology outline

Exam 1 endocrinology outline - Unit 3 Defined chemical...

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Unit 3 Defined chemical bioregulators by mode of transport to target not by chemistry of the molecules, so the same chemical can be neurocrine, hormone and cytocrine. Ex. Somatostatin: in Hypothalamus it’s a neuron hormone In Endocrine pancreas it is a pracrin bioregulator. I. Chemical Categories (Chemical Features to note: Molecular structure Manner of Synthesis rate limiting steps sometimes not an enzyme Method of Transportation to Target Mechanisms of Action ( How the Work) Metabolism (Degredation/Excretion activation of inactivation depends on chemical and what you end up with. ) 1. Amino Acids, Amines, Peptides, Protiens -glutamic acid -epinephrine, serotonin (NTs Hormones) -*Substance P, glucagon -Insulin 2. Steroids a. Steriod hormones (cholesterol is synthesized source of steroid hrms) - steroid nucleus is a cyclopentanoperhydrophenanthrene ring. - Carbons are numbered From Fig 3-24A Norris 2007 - This is a general cholesterol structure b. Stereoisomers - same Molecular weight and same number of carbons but are arranged isometrically - Carbons to keep in mine 3,5,11,17 - α - away from you ---- OH - β - towards you _____ - 17 β -Estradiol is most commonly occurring estrogen
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- 17 β - I. Chemical categories A. Steroid hormones 4. Steroidogenesis 3. Groups of Steroids (based on func and number of Cs) a. Estrogens C 1 8 b. Androgens C19 E 2 E 3 E 1 Figure 3-26 Norris, 2007 c. Progestogens C21 help maintain pregnancy
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Figure 3-27, Norris 2007 ( Both cortico and proges have 21 carbons, but if they lack C11 they can’t bind )**
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Exam 1 endocrinology outline - Unit 3 Defined chemical...

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