06 Biotech Projects

06 Biotech Projects - Biotechnology Products Biotechnology...

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Unformatted text preview: Biotechnology Products Biotechnology: Applications of DNA Manipulation • The ability to clone genes has made possible many new applications of biotechnology, such as the large-scale production of eukaryotic gene products. figure 17-13.jpg figure 17-13.jpg Biotechnology: Applications of DNA Manipulation • Recombinant DNA and expression vectors have been used to make medically useful proteins that would otherwise have been difficult to obtain in necessary quantities. 17.14 figure 17-14b.jpg figure 17-14b.jpg 17.1 Table 17.1 table 17-1.jpg table 17-1.jpg Biotechnology: Applications of DNA Manipulation • Because plant cells can be cloned to produce adult plants, introduction of new genes into plants via vectors has been advancing rapidly. The result is crop plants carrying new, useful genes. Review Table 17.2 table 17-2.jpg table 17-2.jpg Biotechnology: Applications of DNA Manipulation • “Pharming” uses trangenic dairy animals that produce useful products in their milk. Review Figure 17.15 17.15 Figure 17.15 figure 17-15.jpg figure 17-15.jpg Erythropoietin is a naturally occurring hormone secreted mainly by the kidney. It stimulates the bone marrow and increases red blood cells production. This leads to an increase in red blood cell mass, in particular hemoglobin and hematocrit. Recombinant human erythropoietin (rHuEPO) has been available since 1985. Its main clinical use has been in the treatment of anemia caused by renal disease. www.cafdis-antidoping.net/documents/ Case Study 1: Erythropoietin (EPO) Clinical uses for EPO • Anemias due to – Kidney failure – Chemotherapy (cancer) – AIDS treatment (AZT) • Market Size: $5-10 billion/year EPO is banned for use by athletes. As EPO causes an increased red cell mass, extra oxygen-carrying capacity is achieved; this, in turn, permits an increase in energy production by aerobic oxidation of glucose and free fatty acids. This is the most efficient route of energy production. Aerobic oxidation is the most important energy source for endurance athletes. EPO provides the benefits of blood doping without the risk of blood transfusion....
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This note was uploaded on 02/27/2008 for the course CHEN 1000 taught by Professor Degrazia,j during the Fall '04 term at Colorado.

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06 Biotech Projects - Biotechnology Products Biotechnology...

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