Disorders of the Immune System 2.Differentiate between the etiology, clinical manifestations and pathophysiology ofselect disorders of the immune system. a. Evaluate the etiology, clinical manifestations and pathophysiology of Type I, Type II, Type III, and Type IV hypersensitivities and describe the implications clinical practice. Hypersensitivity Etiology Clinical Manifestations Pathophysiology Type I (IgE-Mediated Hypersensitivity Reactions) Mediated by antigen- specific IgE and the products of tissue mast cells. Most type I reactions occur against environmental antigens Acute inflammatory response IgE has a relatively short life span in the blood b/c it rapidly binds to very-high- affinity Fc receptors on the plasma membranes of mast cells. With further exposure of antigen to sensitized individual- one molecule of antigen may bind simultaneously to 2 molecules of IgE-Fc receptor on mast cell, activating intracellular signaling pathways and mast cell degranulation Type II (Tissue-Specific Hypersensitivity Reactions) Characterized by a specific cell or tissue being the target on an immune response. “tissue specific antigens”- are Determined by which tissue or organ expresses the particular antigen. 1. Cell can be destroyed by antibody and activate the complement cascade through the classical pathway, resulting in
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- Fall '15
- cells, secondary immune response, Clinical Practice, Immune Response- IgM