Lecture7_08_Handouts

Lecture7_08_Handouts - 1 Lecture 7 – DNA replication...

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Unformatted text preview: ¡ 1 Lecture 7 – September 18, 2008 DNA replication Introductory concepts DNA replication: Why? High accuracy: Why? Base-pairing enables DNA replication, as each strand can act as a template for the synthesis of a new complementary strand Green = G Blue = A 1 ¡ 2 The Meselson and Stahl experiment http://highered.mcgraw-hill.com/olc/dl/120076/bio22.swf The ability of each DNA strand to act as a template enables a cell to copy (or replicate ) its genes before passing them on to its daughter cells 2 ¡ 3 To be used as a template the double helix must first be opened and the two strands separated A piece of DNA can be inserted into a plasmid to determine if it contains a replication origin DNA molecules in the process of being replicated can be observed by electron microscopy 3 ¡ 4 DNA polymerase synthesizes new DNA by adding nucleotides to the 3’ end of a growing strand At the replication fork, the two newly synthesized DNA strands are of opposite polarity The DNA strand whose 5’ end must grow is synthesized discontinuously in successive separate small pieces called Okazaki fragments 4 ¡...
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This note was uploaded on 02/11/2009 for the course BIOL 2104 taught by Professor Dcimini during the Spring '08 term at Virginia Tech.

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Lecture7_08_Handouts - 1 Lecture 7 – DNA replication...

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