BME 177T - Stem Cell Presentation

BME 177T - Stem Cell Presentation - An Introduction to Stem...

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Click to edit Master subtitle style 9/30/09 An Introduction to Stem Cells followed by Presented By: Anil Kanungo
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9/30/09 Outline Part 1: Part 2: Introduction to Stem Cells: Definition Cultivation Potency Properties Minor Major Engineering the Stem Cell Microenvironment: Importance of Microenvironment Components of Microenvironment Soluble Factors Important Soluble Factors Extracellular Matrix
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9/30/09 Definition Stem Cells: Cells that have the ability to perpetuate themselves through self-renewal and to generate mature cells of a particular tissue through differentiation.
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9/30/09 The Process 1. Embryo Forms 2. Embryo Divides (1-5 Days) 3. Stem Cells begin to form along inside of Blastocyst (5-7 Days) 4. Stem Line 5. Tissue Production
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9/30/09 The Process
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9/30/09 Types of Potency Totipotent: Stem cells produced from the fusion of an egg and sperm cell. Pluripotent: Descend from totipotent stem cells and can differentiate into cells derived from the 3 germ layers (which give rise to all of an animal’s tissues and organs through organogenesis) Multipotent*: Type of stem cell that can produce only cells of a closely related family of cells.
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9/30/09 Where are they? Gut Skin Gonads Umbilical Cord Bone Marrow Liver Brain (recently)
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9/30/09 Properties of Stem Cells Major: Self-Renewal ( intrinsic and extrinsic ) Potential to Differentiate Minor: Asymmetric and Symmetric Cell Division Self-Renewal Capacity Ability to Exist in Quiescent Form Can clonally regenerate into all different cell
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9/30/09 Minor Properties
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9/30/09 Symmetric and Asymmetric Divisions Stem cells can produce one differentiated (or “progenitor”) cell and one that is still a stem cell Stronger evidence for this to be symmetric in mammalian systems Symmetric division allows size of cell pool to be regulated “S” represents stem cell and “P” represents progenitor
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9/30/09 Self-Renewal Capacity Stem cells do not have unlimited self-renewal capacities Stem cells have been shown to last for at least the lifetime of mice, but it has not been determined if this is true for longer lived organisms Fetal and embryonic stem cells are clear cases of stem cells that exist only transiently during development
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Quiescence Better described as “Mitotic Quiescence”
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This note was uploaded on 02/12/2009 for the course ARC 308 taught by Professor Speck during the Spring '08 term at University of Texas at Austin.

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BME 177T - Stem Cell Presentation - An Introduction to Stem...

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