{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

BME 177T - Stem Cell Presentation

BME 177T - Stem Cell Presentation - An Introduction to Stem...

Info icon This preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
Click to edit Master subtitle style 9/30/09 An Introduction to Stem Cells followed by Presented By: Anil Kanungo
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 Outline Part 1: Part 2: Introduction to Stem Cells: Definition Cultivation Potency Properties Minor Major Engineering the Stem Cell Microenvironment: Importance of Microenvironment Components of Microenvironment Soluble Factors Important Soluble Factors Extracellular Matrix
Image of page 2
9/30/09 Definition Stem Cells: Cells that have the ability to perpetuate themselves through self-renewal and to generate mature cells of a particular tissue through differentiation.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 The Process 1. Embryo Forms 2. Embryo Divides (1-5 Days) 3. Stem Cells begin to form along inside of Blastocyst (5-7 Days) 4. Stem Line 5. Tissue Production
Image of page 4
9/30/09 The Process
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 Types of Potency Totipotent: Stem cells produced from the fusion of an egg and sperm cell. Pluripotent: Descend from totipotent stem cells and can differentiate into cells derived from the 3 germ layers (which give rise to all of an animal’s tissues and organs through organogenesis) Multipotent*: Type of stem cell that can produce only cells of a closely related family of cells.
Image of page 6
9/30/09 Where are they? Gut Skin Gonads Umbilical Cord Bone Marrow Liver Brain (recently)
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 Properties of Stem Cells Major: Self-Renewal ( intrinsic and extrinsic ) Potential to Differentiate Minor: Asymmetric and Symmetric Cell Division Self-Renewal Capacity Ability to Exist in Quiescent Form Can clonally regenerate into all different cell types of the tissue in which it exists
Image of page 8
9/30/09 Minor Properties
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 Symmetric and Asymmetric Divisions Stem cells can produce one differentiated (or “progenitor”) cell and one that is still a stem cell Stronger evidence for this to be symmetric in mammalian systems Symmetric division allows size of cell pool to be regulated “S” represents stem cell and “P” represents progenitor
Image of page 10
9/30/09 Self-Renewal Capacity Stem cells do not have unlimited self-renewal capacities Stem cells have been shown to last for at least the lifetime of mice, but it has not been determined if this is true for longer lived organisms Fetal and embryonic stem cells are clear cases of stem cells that exist only transiently during development
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
9/30/09 Quiescence Better described as “Mitotic Quiescence” Shared by some but not all stem cells Gives stem cells the ability to divide slowly or rarely
Image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern