April 11 - April 11, 2008 Cells of the gastric glands o...

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April 11, 2008 Cells of the gastric glands o Mucous neck cells – secrete mucus o Parietal cells Hydrochloric acid (HCl) Function of HCL: o Denaturation of proteins o Kills pathogens in the ingested food o For activation of pepsinogen (zymogen – inactive enzyme) to pepsin (active protein – digestive enzyme) Intrinsic factor Required for the absorption of vitamin B12 in the ileum of the small intestine Vitamin B12 is required for RBC synthesis Lack of vitamin 12 – pernicious anemia (macrocytic anemia) o The high HCL content in the stomach can corrode or destroy the epithelial lining of the gastric wall o Gastric mucosal barriers prevent corrosion of the gastric wall – 3 ways gastric wall corrosion is prevented 2 layers of thick alkaline mucus protect the surface of the wall – acidic gastric content in contact with the gastric neutralized Epithelial cells form tight junction (impermeable junctions) which will prevent acidic gastric content from leaking into the gastric wall Exfoliation – the epithelial cells are replaced every 3-6 days – any worn out cell will be replaced 3
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April 11 - April 11, 2008 Cells of the gastric glands o...

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