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Handout 1 - Student Edition

Handout 1 - Student Edition - BIBC 102 Metabolic...

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BIBC 102: Metabolic Biochemistry (Prof. Scheffler) TA: Edward Chen [email protected] OH: Mondays 4-5pm @ CLICS Handout #1 I. Enzyme a. Function Enzyme is a catalyst that speeds up rate of reaction by lowering activation energy. b. Classification (LNC p. 192) c. Specificity Enzymes are very selective. Two models for formation of enzyme-substrate complex: 1. Lock and key model (lock = enzyme, key = substrate) 2. Induced fit (conformation change at active site where the enzyme changes) d. Thermodynamics General Reaction: E + S ES EP E + P a. Enzymes do nothing to G. They only affect ∆G b. Enzymes alter the activation energy by stabilizing the transition state. e. Kinetics 1 st order rxns: [A] = [A o ]e -kt or ln [A] = ln [Ao] x -kt Reaction Rates: aA + bB → cC + dD K eq = [P]/[S] = [C] c [D] d / [A] a [B] b and ∆G ‘o = -RT ln K eq (if k > 1, ∆G < 0 → rxn forward) (if k < 1, ∆G > 0 → rxn backwards) When k = 0 → equilibrium m = -k ln [Ao]
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BIBC 102: Metabolic Biochemistry (Prof. Scheffler) TA: Edward Chen [email protected] OH: Mondays 4-5pm @ CLICS 2 nd order rxns: 1/[A] = 1/ [Ao] + kt
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