ProblemSet1-3

ProblemSet1-3 - BMB100B Winter 2009 Rubin Problem Set #1...

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BMB100B Winter 2009 Rubin Problem Set #1 Due Tuesday, January 13 th 10:00 A.M. 1) Explain the following generalities regarding amino acid types in alpha helices. a) Prolines are rarely found in the middle of helical sequences. b) Glycines are rarely found in the middle of helical sequences. c) Negatively charged amino acids are commonly found at the beginning of helices. d) Polyalanine has a high propensity to form an alpha helix, while polyphenylalanine does not. e) Polyglutamate only forms an alpha helix at very low pH. 2) The exteriors of water-soluble proteins contain amino acids in loops and conformations that lack secondary structure elements. On the other hand, amino acids in the interior are almost exclusively found in α helices or β sheets. Explain why this is true. 3) The isoelectric point (pI) is defined as the pH at which a molecule has a net neutral charge. a) Is the pI of the tripeptide Ala-His-Ala above, equal to, or less than 6? Explain. b) Calculate what percent of histidines in a solution of Ala-His-Ala are protonated at
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ProblemSet1-3 - BMB100B Winter 2009 Rubin Problem Set #1...

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