BIBC100WI09Midtermkey

BIBC100WI09Midtermkey - Name:_ Student ID #:_ (last, first)...

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Name:_____________________________ Student ID #:_______________________ (last, first) BIBC 100 Midterm Winter 2009
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Name:_____________________________ Student ID #:_______________________ (last, first) Section One. Answer all questions in this section. Two points each. Sketch the R group structure, and give the one letter code for the following amino acids: 1) Glutamate E Find the structure of the R group in Figure 3-5 2) Threonine T 3) Glycine G 4) Leucine L 5) Phenylalanine F 6) Some amino acids have R groups that are normally ionized at pH 7, but are not charged at pH 12. Sketch one of these R groups, and give the one letter code. Lysine or Arginine (K or R) – No H+ to pick up and become charged at pH 12 7) Sketch the R group for the amino (technically “imino”) acid that has its R group covalently bonded to its main chain nitrogen atom. Proline
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Name:_____________________________ Student ID #:_______________________ (last, first) 8) Name a single unusual amino acid – not one of the standard 20 – that is sometime found in proteins (hint: collagen). 4-hydroxyproline, also see Figure 3-8 9) When a single polypeptide chain forms two or more units that are independently stable and could fold separately, we refer to these units as ___ domains _________. 10) What is the net charge of this small peptide at pH 7? FTSSDNQWGRKAVYLI +1 11) Two amino acids of the standard 20 contain sulfur atoms. They are: cysteine and methionine (C and M) 12) Name four different atoms that are present in the prosthetic group of hemoglobin: Iron (Fe), Carbon (C), Oxygen (O), Hydrogen (H), Nitrogen (N) 13) You run a BLAST analysis of your favorite protein and the computer output shows 4 matches with E (expect) values of 5e-34, 8e-98, 2e-10 and 3e-54. Which of these E values corresponds to the BLAST match that is most similar to your favorite protein? 8e-98 The lowest number in scientific notation is the most similar. 14) Show the definition of K d (dissociation constant) when a protein has a single binding site for a ligand. Kd = [P] [L] / [PL]
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BIBC100WI09Midtermkey - Name:_ Student ID #:_ (last, first)...

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