January 8th - CHSC 3P91 January 8th, 2008 Basics Myocardial...

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CHSC 3P91 January 8 th , 2008 Basics Myocardial Ischemia: heart muscle not receiving enough O2 due to narrowed coronary artery. Angina: type of temporary chest pain, pressure or discomfort. Myocardial Infarction: cell death/necrosis of the heart tissue. Monocytes: mature into macrophages, which are important germ fighting cells. Macrophages: phagocytic cell that protects this body against infection and noxious substances. Lymphocytes: 20-30% of all white blood cells; they play a role in immunity. Thrombogenic: promote coagulation Proliferative: to grow by rapid production of new parts/increase in # Endothelial Dysfunction: injury to the endothelium = PRIMARY EVENT Response to injury “hypothesis” Arterial Wall 3 Layers o Intima = Inner o Media = middle o Adventitia = outer Endothelial Cells - metabolically active barrier between blood and vessel - serves structural metabolic and signaling functions that maintain integrity of vessel wall - tightly joined to prevent lg. molecule passage - have anti-thrombotic molecules attached or in their secreted form. in response to sheer stress or neurogenic signals, they secrete substances to
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This note was uploaded on 04/21/2008 for the course CHSC 3P91 taught by Professor O'leary during the Spring '08 term at Brock University, Canada.

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January 8th - CHSC 3P91 January 8th, 2008 Basics Myocardial...

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