Lecture 1 review of BLG311 W2016 - Review of BLG311 Cell...

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Biology: The Dynamic Science
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Chapter 9 / Exercise 11
Biology: The Dynamic Science
Hertz/Russell
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Review of BLG311 Cell Biology IReview of BLG311 Cell Biology I1Review of BLG 311 Cell BiologySaric et al., 2015. Mol. Bio. Cell.
We have textbook solutions for you!
The document you are viewing contains questions related to this textbook.
Biology: The Dynamic Science
The document you are viewing contains questions related to this textbook.
Chapter 9 / Exercise 11
Biology: The Dynamic Science
Hertz/Russell
Expert Verified
LECTURE SECTION: Relevantreview of BLG 311 Cell Biology IOUTLINE AND GOALS:Protein phosphorylation and GTPasesVisualizing cells:Fluorescence microscopyGFPMembrane structureThe lipid bilayer and select propertiesMembrane proteinsMembrane protein organization and functionMembrane transportPermeabilityPassive transport by transportersActive transport by pumpsIon channels2Review of BLG 311 Cell BiologyVesicular transportMembrane fission, targeting and fusionExocytosis/SecretionEndocytosis and endosomal trafficking
Review of BLG 311 Cell Biology3Key concepts to keep in mind:Protein structure: amino acids, primary through quaternary structure – Chapter 3, pg. 109-118, more in BCH 261Energetics – Chapter 2, pg. 51-53, more in BCH 261What enzymes do and how – Fig. 2-21; Chapter 3: 140-144; more in BCH 261; Regulatory mechanisms: GTPases and protein phosphorylation;
Review of BLG 311 Cell Biology4Key concepts to keep in mind I: Protein structure and protein-ligand interactionsFigure 3-1; 3-4, 3-10, 3-37 Molecular Biology of the Cell(© Garland Science 2015)
Review of BLG 311 Cell Biology5Key concepts to keep in mind II: EnergeticsFigure see 2-9; 2-14, 2-16Molecular Biology of the Cell(© Garland Science 2015)
Review of BLG 311 Cell Biology6Key concepts to keep in mind III: enzymes catalyse reactions by lowering activation energyFigure 2-21 Molecular Biology of the Cell(© Garland Science 2015)
Review of BLG 311 Cell Biology7
Question: How do cells change the conformation of a protein?
Figure 3-61 Molecular Biology of the Cell(© Garland Science 2015)Protein phosphorylation is an important signaling switch
8Review of BLG 311 Cell Biology
Figure 3-68 Molecular Biology of the Cell(© Garland Science 2015)GTPases are molecular switches9Review of BLG 311 Cell Biology
VISUALISING CELLSCHAPTER 9: 579-598; 604-61110Review of BLG 311 Cell Biology
Resolution, limit of resolution and microscopesResolution is the ability to see individual objects as individual objectsMicroscopes magnify and increase the resolution of imagesElectron microscopes have 0.002 nm resolutionfor a light microscope the distance below which distinct objects will appear as a single object is at least 0.2 m apart).limit of resolution is the limiting separation at which two objects appear distinct is called the limit of resolutiondepends on the wavelength of the light and the numerical aperture of the lens system usedLight microscopes have a resolution limit of ~0.2 mFigure 9-2 Molecular Biology of the Cell(© Garland Science 2008)11Review of BLG 311 Cell Biology
Review of BLG 311 Cell Biology12-Fluorescence describes light emission that continues

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