150-07lipidsandmembranes[1]

150-07lipidsandmembranes[1] - Foundations of Biological...

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Foundations of Biological Science I (BioSci 150) C Lipids and Membranes The role of hydrophobic interactions in cells
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Foundations of Biological Science I (BioSci 150) C Simplest lipids: hydrocarbons (oil, gas), Cells do not make hydrocarbons (CH 4 is an exception. Cellular lipids: hydrocarbons with functional groups. Even with polar functional groups, cellular lipids are insoluble. Life’s hydrophobic molecules
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Foundations of Biological Science I (BioSci 150) C Three Major Classes of Lipids triglyceride Phospholipid, cell membrane component polar (hydrophilic) side hydrophobic side Fig 6.4 0 membranes hormones, e.g., cortisone, testoseterone, estrogens etc.
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Foundations of Biological Science I (BioSci 150) C Phospholipids and other molecules with hydrophilic and hydrophobic sides are amphipathic Fig 6.6 hydrophilic ‘head’ region hydrophobic ‘tail’ region Phospholipids 0
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Foundations of Biological Science I (BioSci 150) C Human cell Mouse cell Mouse 1/2 Human 1/2 Cell fusion time Human & mouse membrane proteins differ. Antibodies to human & mouse membrane proteins ( , ) bind only to human & mouse cells respectively: 0 Properties of Membranes Conclusion: the plasma membrane is ‘fluid’
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Foundations of Biological Science I (BioSci 150) C Cellular membranes are a mosaic of proteins embedded in a phospholipid bilayer ...
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Foundations of Biological Science I (BioSci 150) C True cell membrane synthetic membrane Evidence for the mosaic ... some proteins span the phospholipid bilayer; freeze-fracture EM :
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Foundations of Biological Science I (BioSci 150) C Details of the Fluid Mosaic Membrane Model ‘Sea of’
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Foundations of Biological Science I (BioSci 150) C Cholesterol, unsaturated fatty acids and temperature affect membrane fluidity liposome (synthetic P-lipid vesicle) minus cholesterol
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150-07lipidsandmembranes[1] - Foundations of Biological...

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