Lecture 12 - Genomics

Lecture 12 - Genomics - Genomics genomes as whole entities...

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Genomics genomes as whole entities A) Gene Structure C) Evolutionary Relationships B) Gene Function D) A Predictive Tool for Novel Genes - biology and computing methods (bioinformatics) gave rise to gene product predicting algorithms - predicted from ORFs, more than 100 codons without a STOP, and confirmed by Expressed Sequence Tags - Intron-Exon boundaries predicted from conserved sequences (5’) and resumption of ORF - May show evidence of genome modification/duplication (transposons) - Syntenic comparison made between paralogues in different species (orthologues) o Determine function (regulation) - Conserved function amino acid similarity: comparison of query protein to known protein gives clues to function - Sequence does not have to be identical: residues can be replaced by similar (also hydrophobic, charged) residue and still conserve function of domain - Queried via BLAST compare against available organismal databases - Scores p-value: probability similarities caused by chance o
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Lecture 12 - Genomics - Genomics genomes as whole entities...

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