Lecture 1 Eukaryotic Transcription

Lecture 1 Eukaryotic Transcription - Eukaryotic...

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Eukaryotic transcription - mechanistically and biochemically similar to prokaryotic (bacterial) transcription in general terms (requirement for RNA polymerase, nucleotides, bond formation) - more complex, especially initiation o Respond to cues in developmental changes associated with embryogenesis and cell differentiation - Restricted to plastids, mitochondria (similar to prokaryote) and nucleus Three polymerases that have specified tasks RNA Pol I transcribe ribosomal RNA genes in nucleolus, 28S, 5.8S, 18S RNA Pol II transcribe all protein encoding genes (mRNA) plus from RNAs for splicing other small non-conding functional RNAs RNA Pol III transcribe ribosomal RNA genes outside the nucleolus (5S), transcription of tRNA genes and small RNAs including U6 (splicing) Common features of RNA polymerases: - multimeric protein complexes, consisting of more than ten subunits - some subunits show significant homology with bacterial RNA polymerase core subunits (common evolutionary origin) - all subunits are more or less essential (yeast lacking one cannot survive)
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Lecture 1 Eukaryotic Transcription - Eukaryotic...

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