Lecture 9 - Signalling

Lecture 9 - Signalling - Cell Signalling Hormones Anabolic...

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Cell Signalling Hormones Anabolic steroid hormones and Human Growth Hormone for sport dependent on muscle mass - mimic natural hormones, disrupt balance affect growth, behavious - rapid acting with many side effects Blood doping for endurance sports - erythropoietin to induce RBC synthesis (instructs maturation of certain lineages) Anabolic steroids: mimic androgens (testosterone) that interact with nuclear hormone receptors - androgen receptor binds DNA to activate transcription of androgen-responsive gene targets Growth Hormone: Peptide that binds to receptor and activates responsive genes to change growth rate of cell cell surface receptors mediate extracellular information to the nucleus EPO is a cytokine - Most cytokines have similar structure emerged from single ancestral molecule - Cytokine binding promotes dimerization of their similar cell surface receptors - transduce their signal through a similar intracellular pathway. - Specificity achieved through TFs present in the cell and genes that are responsive EPO receptor (cell surface) is associated to JAK
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This note was uploaded on 04/22/2008 for the course BIOL 200 taught by Professor Bureau during the Fall '06 term at McGill.

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Lecture 9 - Signalling - Cell Signalling Hormones Anabolic...

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