Lecture 6 - 7 - Protein synthesis

Lecture 6 - 7 - Protein synthesis - Protein synthesis...

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Protein synthesis Transcription: nucleus, translation: cytoplasm Nuclear pores on the nuclear envelope which is water impermeable Mega complex controls flow of proteins in snRNPs - nuclear import receptors a/b IMPORTINS bind to concensus nuclear localization signal (NLS) - proteins may also contain an nuclear export seauence (NES) if leaving hnRNP (heterogeneous ribonucleicprotein particles) form on nascent transcrips - nascent mRNA binds to hnRNP and matures into mNRP complexes (Balbani ring) - mNRPs associate with Nuclear Pore Complex and thread their cargo through the NPC via the major mRNA exporter o most mRNPs exported through this major mRNA exporter - C-terminal and middle of mRNA associate with the FG (phenylalanine and glycine repeat region) in the FG nucleoporin – FG is very hydrophobic - 5’ end goes through first (polarity is determined by ribozymal recognition) - Vectorial transport may be dependent on concentration gradient, but is unknown Pre-tRNAs are processed after RNAP III transcription to yield mature tRNAs 1. 5’ end sequence is removed 2. a short intron is removed 3. CCA is added to the 3’ end 4. internal bases are greatly modified rRNA (80% of cellular content) is greatly transcribed to meet demands Eukaryotic rRNA is transcribed in units comprising the 18S, 5.8S and 28S (in this invariant order) rRNAs -
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This note was uploaded on 04/22/2008 for the course BIOL 200 taught by Professor Bureau during the Fall '06 term at McGill.

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Lecture 6 - 7 - Protein synthesis - Protein synthesis...

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