Serological Diagnosis of Infectious Disease

Serological Diagnosis of Infectious Disease - Unit3...

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MLS 494 Clinical Immunology Unit 3 Serological Diagnosis of Infectious Disease Unit 3 At the conclusion of this unit the student will be able to: Bacterial Infections 1. Describe how the human immune system responds after exposure to bacterial, fungal, viral and parasitic diseases. 2. Identify the organisms and tests that have been categorized as “febrile agglutinins”: (Torch tests) 3. Describe the antibody response and the purpose of the following Group A Beta Strep enzymes: Streptolysin O, Streptolysian A, hyaluronidase, and DNase 4. Discuss the immune response in Strep toxic shock syndrome and the effects of a superantigen 5. Describe the principle of the streptozyme test Parasite and Fungal Infections 1. Describe the laboratory diagnosis of: Histoplasmosis, Aspergillosis, Coccidioimycosis, Blaslomycosis, Sporatrichosis, and Cryptococcus 2. Describe the etiology, epidemiology, and immunologic manifestation of Toxoplasma infection, including the AIDS patient complications 3. Describe the signs and symptoms of acquired and congenital toxaplasmosis 4. Review the IgG and IgM titers that would indicate parasitic infection within the last four months, within the last 18 months, and at least 12 months ago Spirochite Diseases 1. Review the immune response after exposure to syphilis 2. Compare and contrast the progression of syphilis through the stages of the infection 3. Compare and contrast the methodology of screening and confirmatory testing used in the diagnosis of syphilis including nontreponemal and treponemal methods 4. Discuss the etiology and immune response to Lyme disease 5. Name the causative agent for syphilis 6. Describe the immunologic testing for Lyme disease, human Ehrlichosis, and Babesiosis Viral Infections 1. Describe the laboratory detection of human herpesvirus I and II, Varicella­zoster, and Human Herpesvirus 6 2. Identify the disease characteristics of cytomegalovirus (CMV) 3. Describe the immunological testing for CMV 4. Explain the diagnostic evaluation and testing procedures for EBV infection 5. Compare and contrast hepatitis A, B, C, D, E, and G with regard to etiology, transmission incubation, symptoms, and diagnostic evaluation 6. Contrast Hepatitis B antigens and antibodies in regards to the Dane particle, HBsAg, HBeAg, anti­HBc, anti­HBs, anti­HBe, and the stages of infection in which they appear 7. Describe the etiology, epidemiology, and immunologic manifestation of rubella infections 8. Review the relationship between IgM and IgG antibodies and their appearance in the course of disease 9. Examine the identification methods used to differentiate the three heterophil antibody groups in EBV testing 10. Compare and contrast acute vs. Chronic HBV infections HIV 1. Classify the viral characteristics, mode of transmission, immunologic, and cellular manifestations of HIV­1 infection 2. Identify the proteins of serodiagnostic importance in HIV testing 3. Discuss the CD4:CD8 ratio during an HIV infection MLS 494 Clinical Immunology Unit 3 Serological Diagnosis of Infectious Disease Discussions I.
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