Exam III - Spring 2008 (KEY) - NAME: NETWORK ID: MCB 408,...

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NAME: NETWORK ID: MCB 408, Exam III April 3, 2008 Multiple Choice: Choose the BEST answer from the choices A – D. Please read all questions carefully! 1. Which of the following cytokines is involved in inducing an inflammatory response? A. IL-17 B. IL-10 C. TGF- β D. Foxp3 2. Which of the following statements regarding Natural Killer cells is FALSE: A. NK cells contain granzyme and perforin granules B. NK cells target cells with abnormally low levels of class I MHC C. NK cells develop in the thymus D. NK cells express both activating and inhibitory receptors 3. The following steps are involved in proximal T cell receptor signaling. Which of the following options describes the correct order of events? I. Phosphorylation of ZAP70 II. p56 Lck -mediated phosphorylation of ITAMs III. Phosphorylation of LAT and other adaptor molecules IV. Binding of ZAP70 to CD3 zeta chains A. IV, I, III, II B. II, I, IV, III C. I, IV, II, III D. II, IV, I, III 4. In the thymus, the positive selection process results in apoptosis of T cells that: A. Recognize both MHC class I and MHC class II B. Recognize self-peptides C. Have high affinity interactions with foreign peptides D. Do not recognize either MHC class I or MHC class II 5. Which of the following statements regarding Type I cytokines is TRUE: A. They contain an immunoglobulin domain B. They are mostly monomeric C. They are characterized by the expression of two adjacent cysteines D. All of the above statements are true
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2 6. Which of the following statements is FALSE about Type I diabetes? A. It involves the destruction of pancreatic beta cells B. Insulin and GAD are possible autoantigens C. It is mediated by both CD4+ and CD8+ T cells D. It is linked to MHC class I alleles 7. In peripheral tolerance, interaction of TCRs with antigen presenting cells that lack a ligand for the second signal leads to: A. Anergy B. Proliferation C. Apoptosis D. Differentiation 8. In order to better understand the role of CTLA-4 in peripheral T cell tolerance, researchers treated mice with either a control hamster antibody (Ham. Ig) or with a hamster antibody against CTLA-4 (Anti-CTLA-4). One day later, they attempted to induce tolerance by repeatedly injecting a high dose of an antigen (i.e. chronic exposure). Tolerance induction consisted of mice receiving daily injections for 6 days of either a control peptide (solid black bar) or a peptide named PLP (diagonal lined bar). Following the last peptide injection, mice from both groups were injected in the ear with PLP and the cellular immune function was determined through measurements of ear swelling (y-axis). Swelling of the ear is indicative of an active T cell mediated reaction. What conclusions can be made regarding the data shown below? A.
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Exam III - Spring 2008 (KEY) - NAME: NETWORK ID: MCB 408,...

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