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3.4 The Liver - 3.4 THE LIVER-in the centre of the body...

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3.4 THE LIVER -in the centre of the body, near the diaphragm and under the ribs Hepatocytes: liver cells -has a huge blood supply -70% of blood comes from the intestines via the portal vein Liver: a gland that is composed of many acini -centre of the acinus is the portal triad, the hepatocytes are lined by sinusoids that flow from the triad to the terminal hepatic (central) vein -the sinusoids are lined by a group of cells that includes endothelial cells, macrophages (aka. Kupffer cells) and lipocytes (Ito cells – store vitamin A) -oxygen tension of blood changes as it moves through the sinusoid -highest tension at triad, lowest tension at central vein Portal triad: a triad of tubes that includes the portal vein, hepatic artery, and the bile duct Canaliculi: small bile passages that collect bile from individual hepatocytes and move it towards the portal triad -gall bladder stores bile -functions of liver (1) Synthetic capacity: produces glucose, lipoproteins, urea, and plasma proteins (2) Catabolic functions: lipid and ketone breakdown (3) Detoxification
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