3.2 The Hematopoietic System

3.2 The Hematopoietic System - 3.2 THE HEMATOPOIETIC SYSTEM...

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3.2 THE HEMATOPOIETIC SYSTEM -blood tests fall under one or more of the following categories: 1. Hematology, the study of the cells of the blood 2. Immunology, the study of components of the immune system including antibody, T cell function, and  antigens 3. Biochemistry, the examination of molecules that include carbohydrate metabolism, lipid metabolism,  plasma proteins, heme metabolism, function of body systems including enzymology and endocrinology 4. Fluids, electrolytes, and acid-base 5. Hemostasis and coagulation 6. Toxicology -almost all normal blood cells originate in the bone marrow -blood cells -erythrocytes -white blood cells -granulocyte neutrophils (most common), eosinophils, basophils, monocytes,  lymphocytes -immature neutrophils are called “band” cells and they are released from the bone marrow when  they are needed -mature neutrophils are called “segmented neutrophils” -platelets hematopoiesis (myelopoiesis):  the production of the cells of the blood -occurs mostly in the bone marrow erythropoiesis:  the production of erythrocytes granulocytopoiesis:  the production of granulocytes thromopoiesis:  the production of platelets -cells are produced, released into the blood and exit as needed -when they leave, RBCs have no more nuclei (just cytoplasm) -RBCs have a defined age -RBCs bend when they move through capillaries when they are young, but become more rigid as they age  and can’t fit through anymore -spleen filters old and young RBCs – old RBCs accumulate and are eaten by macrophages -there is a normal range of cell numbers in the peripheral blood -numbers too high or too low are affected by bone marrow production intravascular destruction or changes  in exit Erythrocytes Pact cell volume (PCV) (aka. Hematocrit):  tests red blood cell mass -cells are counted to give a red cell count (RCC or RBCs)
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This note was uploaded on 04/22/2008 for the course PATH 3610 taught by Professor Foster during the Winter '07 term at University of Guelph.

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3.2 The Hematopoietic System - 3.2 THE HEMATOPOIETIC SYSTEM...

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