sag-44-6-21-1309-87 - Turkish Journal of Medical Sciences Turk J Med Sci(2014 44 1051-1054 TBTAK doi:10.3906/sag-1309-87

sag-44-6-21-1309-87 - Turkish Journal of Medical Sciences...

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1051 Turkish Journal of Medical Sciences Turk J Med Sci (2014) 44: 1051-1054 © TÜBİTAK doi:10.3906/sag-1309-87 Investigation into the frequency of Helicobacter pylori infection with carbon 14 urea breath test in patients with vitiligo Emine Nur RİFAİOĞLU 1, *, Füsun AYDOĞAN 2 , Bilge BÜLBÜL ŞEN 1 , Tuğba ŞEN 1 , Özlem EKİZ 1 1 Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey 2 Department of Nuclear Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey * Correspondence: [email protected] 1. Introduction Vitiligo is an acquired depigmenting skin disorder. It occurs clinically by the appearance of well-circumscribed, asymptomatic, white macules following the loss of functional melanocytes in the epidermis (1). The prevalence rate of vitiligo ranges from 0.06% to 2.28% in the population (2). The main etiopathogenesis of vitiligo is multifactorial. According to various pathophysiological theories, it may be associated with autoimmunity, neurogenic dysregulation, autocytotoxicity, biochemical dysregulation, oxidative stress, and weak melanocyte viability (1,3–6). Several potentially environmental factors such as infectious agents appear to be related with vitiligo (7–9). Helicobacter pylori (HP) is a major health problem affecting about 50% of the world population (10). Gastric ulceration and carcinogenesis are associated with HP infection (11). HP infection has been linked to various autoimmune dermatological diseases, such as alopecia areata, Behçet’s disease, chronic urticaria, pruritus, psoriasis, and rosacea (12–17). The frequency of HP has not been studied in patients with vitiligo. Noninvasive tests such as the carbon 13 or carbon 14 (C14) urea breath test (UBT), stool antigen tests, and serology are used to detect HP infection (18). In this study, we used the C14 UBT to detect the frequency of HP infection in patients with vitiligo. 2. Materials and methods 2.1. Patient and control groups With the approval of the local ethics committee, a prospective study was conducted in our dermatology department clinic. The study comprised 34 patients with vitiligo and 30 age- and sex-matched healthy controls. The patients with vitiligo were newly diagnosed and older than 16 years. The patients with gastrointestinal symptoms or those who had received eradication therapy for HP earlier were excluded from the study. Other exclusion criteria were age under 16 years, pregnancy or lactation, and the use of antibiotics, proton pump inhibitors, or H2 blockers in the 40, 7, and 14 days, respectively, leading up to sample collection. According to the working clinical classification, vitiligo was classified as vitiligo vulgaris, acrofacial, focal, segmental, universal, or mucosal (16). Background/aim: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea
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  • Fall '16
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  • Helicobacter pylori, Vitiligo, hp infection

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