This preview shows page 1. Sign up to view the full content.
Unformatted text preview: the result of the high frequency of the TSD allele to create genetic compounds. pleiotropy (from OMIM entry #310200) The most distinctive feature of Duchenne muscular dystrophy is a progressive proximal muscular dystrophy with characteristic pseudohypertrophy of the calves. The onset of Duchenne muscular dystrophy usually occurs before age 3 years, and the victim is chairridden by age 12 and dead by age 20. ... Mental retardation of mild degree is a pleiotropic effect of the Duchenne gene (Zellweger and Niedermeyer, 1965). variable expressivity penetrance (from OMIM entry #113705): The penetrance of the BRCA1 gene was estimated to be 0.92 by age 70. 25 1 3 2 4 8 1 2 3 5 6 7...
View Full Document
- Spring '08