06Mutation - ser—gln—glu—phe—thr nonsense 5’...

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Mutation Basics Point mutations from the DNA perspective point mutation transition transversion deletion insertion Point mutations from the polypeptide perspective (Fig below) original sequence mutated sequence same-sense 5’ TCT.CAA.AAA.TTT.ACG 3’ sense 5’ TCT.CAA.AAG.TTT.ACG 3’ 3’ AGA.GTT.TTT.AAA.TGC 5’ template 3’ AGA.GTT.TTC.AAA.TGC 5’ ser—gln—lys—phe—thr polypeptide ser—gln—lys—phe—thr missense 5’ TCT.CAA.AAA.TTT.ACG 3’ sense 5’ TCT.CAA.GAA.TTT.ACG 3’ 3’ AGA.GTT.TTT.AAA.TGC 5’ template 3’ AGA.GTT.CTT.AAA.TGC 5’ ser—gln—lys—phe—thr polypeptide
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Unformatted text preview: ser—gln—glu—phe—thr nonsense 5’ TCT.CAA.AAA.TTT.ACG 3’ sense 5’ TCT.CAA.TAA.TTT.ACG 3’ 3’ AGA.GTT.TTT.AAA.TGC 5’ template 3’ AGA.GTT.ATT.AAA.TGC 5’ ser—gln—lys—phe—thr polypeptide ser—gln (stop) frameshift 5’ TCT.CAA.AAA.TTT.ACG 3’ sense 5’ TCT.CAA.GAA.ATT.TAC.G 3’ 3’ AGA.GTT.TTT.AAA.TGC 5’ template 3’ AGA.GTT.CTT.TAA.ATG.C 5’ ser—gln—lys—phe—thr polypeptide ser— gln— glu— ile— tyr Forward mutation vs. reversion forward mutation reversion Suppression 10...
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This note was uploaded on 04/22/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

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