9.27_Types_of_Receptors - Types of Receptors...

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Types of Receptors Intracellular -located within nucleus or cytoplasm -lipophilic ligand/messenger (non-polar) -uses binding protein in plasma ( polar) -why? Protein is amphipathic so it ‘protects’ the ligand when it goes through polar plasma -receptor/ligand complex -in nucleus or enters -alters DNA transcription -transcription factor -transcription suppressor -Membrane bound -hydrophilic ligand (polar) -extracellular binding -1 st messenger -most use a 2 nd messenger system -enter or is w/in cytosol -Relays-membrane bound needs relay to get through cell Four general categories based on impact 1) Function as ion channels -receptor is an ion channel (ligand-gated) -what happens when messenger binds? -conformation change -channel opens/closes -change membrane potential (charge across membrane) 2) Function as enzymes -receptor is an enzyme -protein Kinase tyrosine kinase -Kinase= enzyme that participates in a break down in ATP -What happens when messenger binds? - Conformation change
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This note was uploaded on 04/22/2008 for the course EEOB 232 taught by Professor Bronson during the Spring '07 term at Ohio State.

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9.27_Types_of_Receptors - Types of Receptors...

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