10.11_Muscle_Function - Muscle Function: -Contract -Action...

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Muscle Function: -Contract -Action potential conducted along plasma membrane (into transverse tubercles) -In SR, Voltage-gated Ca channels open -Ca released in cytosol -Ca binds to troponin -Tropomyosin moves myosin site exposed -Myosin (ADP and P1) binds to actin - Cross bridge cycling - (series of conformation D) -Myosin (ADP and P1) binds to actin -Release ADP and P1 -Flex of cross-bridge (movement of muscle) -ATP binds myosin -myosin releases actin -ATP to ADP and P1 (gets crossbridge back) -hydrolazition process -Causes deflex/ cock of cross-bridge -only moves ~10nm -so this process happens a lot and uses a lot of E - Rigor Mortis : (stiffness of body) -set up by crossbridge cycling -All ATP go away when dead cross bridge doesn’t happen -If no ATP myosin remains bound to actin - Sarcomere shortening- (trying to pull on rope; release and pull again) -Sliding with in -thick pulling thin towards M line -Filaments DO NOT contract (D size) themselves -unchanged- A band -Shortened (sarcomere, I band, and H zone)
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This note was uploaded on 04/22/2008 for the course EEOB 232 taught by Professor Bronson during the Spring '07 term at Ohio State.

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10.11_Muscle_Function - Muscle Function: -Contract -Action...

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