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lec 10 - Bioenergetics I Text pages 594-598 180-194 Terms...

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Unformatted text preview: Bioenergetics I Text pages: 594-598 180 -194 Terms from previous lectures Endergonic & exergonic Catabolic & anabolic Exothermic & endothermic Gibbs Free energy - G G = H - TH Spontaneous reactions: -G Oxidation - reduction reactions Terms from previous lectures Electron transport chains ATP Why do organisms use it? Why is it high energy? Chemiosmotic synthesis Table 27.3: Strategies for 27.3 obtaining energy and carbon Sunlight (photosynthesis) Organic molecules with high potential energy via redox reactions Inorganic molecules with high potential energy Basic Concept #1: e- absorb energy from the following sources: Basic Concept #2: high energy ecarried in cell by NAD+ or FAD: NAD+ is reduced to NADH + H+ by picking up a pair of high energy e NADP+ is reduced to NADPH (in plant photosynthesis) FAD is reduced to FADH2 by picking up a pair of high energy e Questions: where do these high energy ecome from and where do they go? Table 27.4: Basic Concept #3: Note that all of these take a high energy e- from a donor that ultimately reduces a final electron acceptor. acceptor So what? Fig. 27.13 Thus organisms can evolve to inhabit a variety of environments! Fig 27.15 Fig 9.1 Fig 9.2 Fig 9.3: + NAD & NADH Bacteriorhodopsin http://pdbdev.sdsc.edu:48346/pdb/molecules/pdb27_1.html http://pdbdev.sdsc.edu:48346/pdb/molecules/pdb27_3.html Fig 9.6 Glycolysis Pyruvate Oxidation Citric Acid Cycle CO 2 Acetyl CoA 2C CO 2 Pyruvate 3C Acetyl CoA 2C + 4 e2 NADH 4C CO 2 6C 5C 4C e- Oxidative Phoshorylation ETS Pyruvate 3C Glucose 6C +4e - CO 2 e +H+O + 2 2 NADH +6 NADH & 2 FADH 2 Water CO 2 ATP NADH FADH 2 4-2=2 By SLP 2 NADH 2 0 4 2 by SLP 6 NADH + 2 FADH 2 32 34 by chemiosmosis 2 NADH Glycolysis Pyruvate Oxidation Citric Acid Cycle CO 2 Acetyl CoA 2C CO 2 Pyruvate 3C Acetyl CoA 2C + 4 e2 NADH 4C CO 2 6C 5C 4C e- Oxidative Phoshorylation ETS Pyruvate 3C Glucose 6C +4e - CO 2 e +H+O + 2 2 NADH +6 NADH & 2 FADH 2 Water CO 2 ATP NADH FADH 2 4-2=2 By SLP 2 NADH 2 0 4 2 by SLP 6 NADH + 2 FADH 2 34 by chemi32 osmosis 2 NADH Glycolysis Pyruvate Oxidation Citric Acid Cycle CO 2 Acetyl CoA 2C CO 2 Pyruvate 3C Acetyl CoA 2C + 4 e2 NADH 4C CO 2 6C 5C 4C e- Oxidative Phoshorylation ETS Pyruvate 3C Glucose 6C +4e - CO 2 e +H+O + 2 2 NADH +6 NADH & 2 FADH 2 Water CO 2 ATP NADH FADH 2 4-2=2 By SLP 2 NADH 2 0 4 2 by SLP 6 NADH + 2 FADH 2 32 34 by chemiosmosis 2 NADH So, what's it to be: 100,000,000 ATPs or 1 Snickers Bar? Your questions? Let's be sure we know where we have been and where we are going! Glycolysis Pyruvate Oxidation Citric Acid Cycle CO 2 Acetyl CoA 2C CO 2 Pyruvate 3C Acetyl CoA 2C + 4 e2 NADH 4C CO 2 6C 5C 4C e- Oxidative Phoshorylation ETS Pyruvate 3C Glucose 6C +4e - CO 2 e +H+O + 2 2 NADH +6 NADH & 2 FADH 2 Water CO 2 ATP NADH FADH 2 4-2=2 By SLP 2 NADH 2 0 4 2 by SLP 6 NADH + 2 FADH 2 32 34 by chemiosmosis 2 NADH Glycolysis CH2OH O OH OH OH OH O - + H+ 2 CH3-C-C-O O C6H12O6 2 C3H4O3 C6H12O6 2 C3H4O3 + 4 e- + 4H+ 2 NAD+ + 4 e- --> 2 NADH +2 H+ to ETS Other terms: Allosteric (other site) inhibition or activation by binding and changing shape of enzyme protein Other terms: Feedback Inhibition: Fig 9.9 product builds up and decreases enzyme activity A --> B --> C + D --> etc. Inhibits Related to Fig 9.9: Feedback Inhibition Fig 9.9 Fig 9.10 Fig 9.16 Fig 9.17 Fig 9.19 Fig 9.20: ATP Synthase Run out of NAD+ due to no oxygen or other e- acceptor? Use fermentation to regenerate NAD+ from NADH and make ATP by SLP!! Fig 9.22a Fig 9.22b Fig 9.22c Fig 9.24: Krebbs Cycle as the `hub' of metabolism Fig 9.25: Catabolic reactions ...
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