Zoology - Lecture 9 - 13.01 DNA to RNA to Protein The...

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1 Cytoplasm Nucleus 13.01 DNA to RNA to Protein RNA Protein Translation The Genetic Code 20 amino acids; 4 nucleotides 1:1 code: only 4 amino acids “doublet” code: only 16 amino acids “triplet” code: 64 amino acids Nirenberg 1961. Decoding the triplet sequence The Genetic Code Nirenberg 1961. Decoding the triplet sequence UUUUUUUUUUUUUUUUUUUUU The Genetic Code Nirenberg 1961. Decoding the triplet sequence PHE PHE PHE PHE PHE PHE PHE The Genetic Code Nirenberg 1961. Decoding the triplet sequence PHE-PHE-PHE-PHE-PHE-PHE-PHE UUU UUC UUA UUG UCU UCC UCA UCG UAU UAC UAA UAG UGU UGC UGA UGG CUU CUC CUA CUG CCU CCC CCA CCG CAU CAC CAA CAG CGU CGC CGA CGG AUU AUC AUA AUG ACU ACC ACA ACG AAU AAC AAA AAG AGU AGC AGA AGG GUU GUC GUA GUG GCU GCC GCA GCG GAU GAC GAA GAG GGU GGC GGA GGG U C A G UCA G U C A G U C A G U C A G U C A G F L L I M or start V S P T A Y stop stop stop H Q N K D E C W R S R G
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2 A = Ala = Alanine C = Cys = Cysteine D = Asp = Aspartic acid E = Glu = Glutamic acid F = Phe = Phenylalanine G = Gly = Glycine H = His = Histidine I = Ile = Isoleucine K = Lys = Lysine L = Leu = Leucine M = Met = Methionine N = Asn = Asparagine P = Pro = Proline Q = Gln = Glutamine R = Arg = Arginine S = Ser = Serine T = Thr = Threonine V = Val = Valine W = Trp = Tryptophan Y = Tyr = Tyrosine 1 & 3 letter code for the amino acids: Code is practically universal Interpreting the Code • Examples: mRNA (codon) = UUA = = AUG = = CCG = = GUG = 13.11 From DNA to RNA to Protein Transcription DNA TTCAGTCAG DNA template strand [120] 13.11 From DNA to RNA to Protein Transcription DNA DNA template strand mRNA AAGUCAGUC Messenger RNA [120] 13.11 From DNA to RNA to Protein Transcription Codon Codon Codon Translation DNA DNA template strand Messenger RNA mRNA [120] 13.11 From DNA to RNA to Protein Transcription Codon Codon
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Zoology - Lecture 9 - 13.01 DNA to RNA to Protein The...

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