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Unformatted text preview: 1 Name_____________________ ID_____________________ BIOM*3090 Principles of Pharmacology and Toxicology Winter Semester, 2005 Midterm Examination Examiner: Dr. G. Kirby February, 2005 Answer all questions on the computer sheets provided using a pencil. There are a total of 50 marks. Multiple choice: (25 marks) 1. You are conducting pharmacokinetic studies for a new drug using a group of 70 kg male volunteers. After a 100 mg dose of was administered and allowed to distribute through the body you determine the concentration of free drug in the plasma to be 20 mg/L What is the apparent volume of distribution of the drug in this group of volunteers? a) 0.6 L b) 5 L c) 60 L d) 100 L e) 1000 L 2. Had the volume of distribution in question 1 been 250 L, what might that indicate about the distribution of this drug in the body? a) The drug readily crosses the vascular endothelium b) The drug is substantially bound to plasma proteins c) The drug is sequestered in various body compartments due to ion-trapping, fat solubility etc d) The drug preferentially distributes to tissues other than blood e) All of the above 3. How can the dosing regimen of a drug with a low therapeutic index be altered in order to DECREASE the difference between the maximum and minimum plasma drug concentrations at steady state? Assume the drug is only administered orally. a) give larger doses b) give smaller doses c) give the drug more frequently d) give the drug less frequently e) a and c 2 Name_____________________ ID_____________________ 4. The two main organs responsible for the elimination of most drugs from the body are: a) Lungs and skin b) Small and large intestines c) Liver and kidneys d) Heart and circulatory system e) All of the above 5. You have accidentally administered too much of a drug that is a weak base to a patient in the intensive care unit where you work. Identify two ways by which you can increase the rate of renal elimination of this drug. a) Administer a urinary acidifier b) Administer antacid tablets to alkalinize the pH of the stomach c) Increase the urine flow rate by giving fluids or a diuretic d) a and c e) a, b and c 6. Which of the following acronyms indicates the safety of a drug? a) USP b) Rx c) SID d) Css e) TI 7. When acetaminophen (a non-steroidal anti-inflammatory drug) is absorbed into the bloodstream most of the drug binds to plasma proteins. How might this event affect the pharmacokinetics and pharmacodynamics of this drug? a) Distribution of the drug is reduced as protein-bound drug cannot leave the circulation b) Metabolism of the drug is reduced as protein-bound drug cannot enter hepatocytes c) Elimination of the drug is reduced as protein-bound drug cannot cross the glomerulus d) Activity of the drug is reduced as protein-bound drug cannot bind to target receptors....
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This test prep was uploaded on 04/22/2008 for the course BIOM 3090 taught by Professor Kirby/kalisch during the Winter '07 term at University of Guelph.
- Winter '07