Final-rev2007 - MCB 4203 Review for Final Exam • Section...

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Unformatted text preview: MCB 4203 Review for Final Exam • Section I. 1. Bacterial Pathogens 2. Host defense mechanisms (including immunological) 3. Antibiotics • Section II. 1. Picornaviruses 2. Herpesviruses 3. Hepatitis viruses • Section III. 1. Staphylococcus spp.and Streptococcus spp. 2. Enterobacteriaceae 3. Aerobic and anaerobic spore-forming bacilli Topics to be covered for the final exam • The following slides represent the main, but not the only, topics to be covered for the final exam • Other material from the sections listed on slide one may be included Bacterial Pathogens • Pathogens - bacteria capable of causing disease • Distinguish between bacteria that are: • Usually pathogens - Yersinia pestis • Opportunisitc infections - Pseudomonas aeruginosa • Non-pathogens Bacterial Virulence • Virulence - relative ability to cause disease • Infectious dose (50) ID 50 • Lethal dose (50) LD 50 Mechanisms associated with disease • Invasion • Toxic products or activities Invasion • Attachment • Obtaining nutrients • Avoid host defenses Bacterial Toxins • Cytolytic toxins - attack surfaces • Exotoxins, enterotoxins - entry of cells is required • Neurotoxins - affect normal nerve function • Endotoxin • Super antigens Activities of major cytokines released during septic shock • IL-1 – causes fever by stimulating prostaglandidn release in the hypothalamus; it contributes to hypotension • TNF – contributes to frver, hypotension, hemorrhages in organs, increased breathing and heart rate • Interferon G – Activates monocytes , may contribute to vascular damage Host Defense Mechanisms • Physical • Chemical - non-specific and specific (immune system) • Nutritional • Host microflora • Cellular Biological activity (bindingcomplement) Antibody activity B cell T - helper cell T - cytolytic cell B cell with Ag - binding receptor (antibody) T cell with T -cell receptor (TCR) and CD4 marker TCR CD4 T cell with T - cell receptor and CD8 marker TCR CD8 Reactions with hydrogen peroxide • Hydrogen peroxide + ascorbate...
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Final-rev2007 - MCB 4203 Review for Final Exam • Section...

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