Final-rev2007 - MCB 4203 Review for Final Exam Section I....

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Unformatted text preview: MCB 4203 Review for Final Exam Section I. 1. Bacterial Pathogens 2. Host defense mechanisms (including immunological) 3. Antibiotics Section II. 1. Picornaviruses 2. Herpesviruses 3. Hepatitis viruses Section III. 1. Staphylococcus spp.and Streptococcus spp. 2. Enterobacteriaceae 3. Aerobic and anaerobic spore-forming bacilli Topics to be covered for the final exam The following slides represent the main, but not the only, topics to be covered for the final exam Other material from the sections listed on slide one may be included Bacterial Pathogens Pathogens - bacteria capable of causing disease Distinguish between bacteria that are: Usually pathogens - Yersinia pestis Opportunisitc infections - Pseudomonas aeruginosa Non-pathogens Bacterial Virulence Virulence - relative ability to cause disease Infectious dose (50) ID 50 Lethal dose (50) LD 50 Mechanisms associated with disease Invasion Toxic products or activities Invasion Attachment Obtaining nutrients Avoid host defenses Bacterial Toxins Cytolytic toxins - attack surfaces Exotoxins, enterotoxins - entry of cells is required Neurotoxins - affect normal nerve function Endotoxin Super antigens Activities of major cytokines released during septic shock IL-1 causes fever by stimulating prostaglandidn release in the hypothalamus; it contributes to hypotension TNF contributes to frver, hypotension, hemorrhages in organs, increased breathing and heart rate Interferon G Activates monocytes , may contribute to vascular damage Host Defense Mechanisms Physical Chemical - non-specific and specific (immune system) Nutritional Host microflora Cellular Biological activity (bindingcomplement) Antibody activity B cell T - helper cell T - cytolytic cell B cell with Ag - binding receptor (antibody) T cell with T -cell receptor (TCR) and CD4 marker TCR CD4 T cell with T - cell receptor and CD8 marker TCR CD8 Reactions with hydrogen peroxide Hydrogen peroxide + ascorbate...
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Final-rev2007 - MCB 4203 Review for Final Exam Section I....

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