Week 8 Assignment 2 - The Pathophysiology of Alzheimers disease Pathophysiology of the alterations Alzheimers disease(AD affects three processes

Week 8 Assignment 2 - The Pathophysiology of Alzheimers...

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The Pathophysiology of Alzheimer’s disease Pathophysiology of the alterations Alzheimer’s disease (AD) affects three processes, metabolism, repair and communication that keep the body neurons healthy. Certain nerve cells within the brains stop working, they lose connection with other cells in the brain and finally die (Curran & Wattis, 2012). The death and destruction of the nerve cells therefore causes failure of the memory, changes in personality, problems with daily activities and other issues related with the disease. NFTs main constituent include the tau, a microtubule associated protein. In AD, hyper phosphorylated tau accumulates, Surprisingly, the mutations of the tau results not in AD but in cases of front temporal dementia. Since time of AD, SPs have been known to include starch like substance that usually occurs at he centre of the lesions. The amyloid substance has a surrounding of a halo of degenerating neuritis and both microglia and astrocytes.
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….Continued The NFTs distribute in medial aspect in temporal lobe and they affect hippocampus severely. SPs also accumulate in association cortices and also in hippocampus. Although NFTs and SPs indicate the presence of AD, they are not pathognomonic. Like the NFTs are in several other disorders like dementia pugilistic. Also, SPs may occur in normal aging. Therefore, the presence of these lesions is not enough evidence for AD. The lesions therefore must be present in large numbers and in distribution to fulfil the criteria for AD (Murray, 2012).
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