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1Application: The Pathophysiology of Alzheimer’s diseaseNURS - 6501N – 3- Advanced PathophysiologyOludotun PetersWalden UniversityAugust 4, 2016
The Pathophysiology of Alzheimer’s The Pathophysiology of Alzheimer’s diseasediseaseThe plagues are insoluble deposits of proteins and cellular materials.Found outside and around the neurons. Made of beta-amyloid, protein fragment from amyloid precursor protein. The fragments clump together with other neurons, molecules and non-nerve cells. In AD, plaques develop in hippocampus and this hampers thinking and decision making. The plaques begin to form in the brains as early as in the fifth decade of life. 2
…….Continued.ContinuedTangles also build up inside the nerve cells. The plaques and tangles built in old people’s brains (Murray, 2012). Are in great number among the people with AD. The cloning of genes, sequence of amino acids and the chemical characterization of amyloid proteins are recent advances (Lu & Bludau, 2011).