Methaqualone - Andrea Sims Toxicology May 4 2007...

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Andrea Sims Toxicology May 4, 2007 Methaqualone Methaqualone is a sedative that was used primarily in the 1960s and ‘70s as a treatment for insomnia, as a sedative, and also as a muscle relaxant. It is a central nervous system depressant. Recreationally, methaqualone use became popular in the 1960’s, of the euphoric effects felt after smoking. South Africa leads the world in abuse of methaqualone, also known as Mandrax, which they crush and smoke in a pipe along with marijuana. In the United States, it is a Schedule I drug. Article 1, “Isolation and Identification of Methaqualone in Post-Mortem Tissues,” details how to find methaqualone from blood, urine, bile, or tissues. For the any of the fluids, the procedure called for diluting blood or urine with HCl, and then autoclaving for 45 minutes. The solutions were then cooled, filtered, and any remaining residue was dissolved in more HCl. Quanitation was then done first using a UV spectrophotometer, then using a gas chromatograph with a flame ionization detector. For tissues, the
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Methaqualone - Andrea Sims Toxicology May 4 2007...

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