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BME501_Muscle_2007 - Contractile filaments Thick filaments...

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BME 501: Neuromuscular System Prof. Gerald E. Loeb, DRB-B12, x11112, [email protected] , office hours by appointment Reading: Chapter 34, Principles of Neural Science, eds. Kandel et al., McGraw-Hill, 4 th ed. 2000. Philosophy of learning as a graduate student: Why study physiology as a biomedical engineer? How to study physiology as a scientist? System Attributes Strength Power Efficiency & Economy Modulation & Control Stability Self-organization Muscle Outside-In Moment Arms Net Torque Multiarticularity Muscle fibers Tendon & Aponeurosis Pinnation Hydrostatics Fibers in Series Endomysium Dystrophin
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Excitation and Contractile Apparatus Intracellular Structure
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Unformatted text preview: Contractile filaments Thick filaments – myosin long chain, short chain, heads Thin filaments – actin, tropomyosin, troponin Stabilizing structures Z-plates Connectin (titin) M-lines Sarcoplasmic reticulum T-tubules Cisternae Longitudinal tubules Action Potentials and EMG Calcium Kinetics Cross-Bridge Formation Cross-Bridge Energetics Stability Motor Unit Organization and Recruitment Motor Unit Definition Muscle Fiber Types and Properties Recruitment Order & Size Principle Motoneuron Recruitment Mechanism Frequency Modulation Review of System Attributes: How does muscle meet requirements?...
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