Handout week 3

Handout week 3 - TA: Paula Patterson OH: Fri 3-4 NSB 4109...

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TA: Paula Patterson Email: pcpatter@ucsd.edu OH: Fri 3-4 NSB 4109 Sxn: Fri 11-1150, 12-1250 Paper 1: Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium Background: Profilin binds to monomeric actin sequestering it from the pool of polymerizable actin monomers. Actin is a 42kDa protein which polymerizes to form thin filaments within a cell. It is a cytoskeleton protein participating in many roles such as motility and cell division Organization: -The genome of the cyanobacterium Microcystis aeruginosa contains a genomic island which encodes proteins with large sequence identity to eukaryotic actin as well as profilin. -These proteins are only located in a strain growing in a particular area and so it is hypothesized that these proteins adapt the bacterium to its niche -These proteins (ActM and PfnM) are encoded 280 nucleotides apart within the genome -BLAST reveals high amino acid sequence identity for ActM(65%) and PfnM(57%) when compared to eukaryotic actins. Such high identity indicates horizontal gene
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This note was uploaded on 04/23/2008 for the course BIMM 120 taught by Professor Larsen during the Winter '08 term at UCSD.

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Handout week 3 - TA: Paula Patterson OH: Fri 3-4 NSB 4109...

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