Lecture10Lifestyle(2)

Lecture10Lifestyle(2) - Volunteer note-taker needed Bio 12D...

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1 Bio 12D Lecture 9 Lifestyle Diseases • Nutrition • Type 2 Diabetes • Heart Disease • Stroke Week 6 Reading Sci Am: “Saving Hearts that Grow Old” Mayo Clinic Guideline on Type 2 Diabetes New Yorker on Pre-eclampsia Homework 5 due Thursday, Feb 21st, in class Volunteer note-taker needed 2 Midterm • Mean = 73 ± 15 3 • Speak louder • Notecards • Answers to lecture questions • Group-work • Level of detail • Video Thank you for thorough and helpful evaluations! 4 Lecture 9 Review
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5 Cell Cycle Oncogenes blast through checkpoints Tumor suppressor genes can’t hold growth back like usual http://teachline.ls.huji.ac.il/72373/substance_x/cell-cycle2.jpe Lecture 9 Review 6 Oncogene : lose control of a growth promoting protein (dominant) – Bcr-Abl Kinase and Chronic Myeloid Leukemia Tumor suppressor : lose control of a protein that normally protects against overgrowth (recessive) – BRCA1 and breast cancer Lecture 9 Review 7 http://video.google.com/videoplay?docid=- 7133914061038033516&q=gleevec&total=11&start=0&num=10&so=0&type=search&plindex=1 Lecture 9 Review 8 ! ! ! !
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9 Lifestyle disease epidemic growing http://blogs.nypost.com/40by40/Fat-Guy-in-Chair-thumb.jpg 10 1998 Obesity Trends* Among U.S. Adults BRFSS, 1990, 1998, 2006 (*BMI ! 30, or about 30 lbs. overweight for 5’4” person) 2006 1990 15%–19% 20%–24% 25%–29% ! 30% 11 Mice lacking leptin become obese http://www.med.umich.edu/opm/newspage/images/mice.jpg -The hormone leptin is released to signal fullness -Obesity often destroys leptin response - Leptin may also influence how much insulin is secreted 12 Modern nutrition guidelines • Individual • Include exercise • Whole-grains and vegetables • Avoid processed foods http://www.mypyramid.gov/
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17 http://cellbio.utmb.edu/cellbio/cholesterol.jpg Cholesterol is important! • Seals cell membrane, prevents water soluble molecules from sneaking in • Keeps membrane tails flexible, so they don’t get locked into place 18 • Most cholesterol is produced by body Less significant amounts found in animal-derived foods http://library.thinkquest.org/11960/nutrition/fats.htm Plants are low in cholesterol: 9.6 liters of peanut oil contains as much cholesterol as one egg 19 http://www.phillips-fit.co.uk/personaltraining/reduced-blood-cholesterol-levels • Cholesterol does not mix well with blood, so it
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Lecture10Lifestyle(2) - Volunteer note-taker needed Bio 12D...

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