lecture12flu+

lecture12flu+ - Bio 12D Lecture 11 I. Infectious Disease...

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1 Bio 12D Lecture 11 I. Infectious Disease Week 8 Reading “Hemagglutinin”, Molecule of the month “Who put the tubercle in tuberculosis?” Nature reviews microbio “Emerging infectious disease”: J Clinical Investigation “1918 Flu Virus Reconstruction”: Washington Post Drug resistant staph infections, NYT Homework 6 due Thursday, Feb 28th 2 Review 3 Bacteria Fungi Parasites Viruses 1. Bacteria are often surrounded by a strong protective cell wall and replicate through simple cell division. 2. Fungi may cause infections of the mouth, throat, lungs, and skin. 3. Parasites thrive on their host, often causing long-lasting chronic infections. 4. Viruses are small packages of genetic material that can only replicate inside cells Copyright © 2006 Dr. Salme Taagepera, http://nobelprize.org/nobel_prizes/medicine/laureates/1997/illpres/novel-inf.html Infectious micro-organisms 4 Bacteria Fungi Parasites Viruses Cholera Thursday: Tuberculosis Black Plague Malaria Influenza Colds Next week: HIV Athlete’s foot, ringworm
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5 Virus Virus Virus Bacteria, virus or parasite Bacteria Parasite 6 • Air travel • dam construction • hot tubs • air conditioning • blood transfusion • deforestation • day care centers • urbanization Social changes that influence spread of microbes 7 Numbers refer to HIV/AIDS patients From J Clin Investigation, Emerging Infectious Disease 8 Virus : bacteria is like Mouse : Human in size
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9 10 Deadliest epidemic? • Influenza (flu) Viral infection Killed 25 million people in one year (1918-1919) Pandemic Started U.S. on March 11, 1918 Spread to every state in one week Philadelphia, Baltimore, Washington DC lost 15% of their population By April: France, China, Japan By May: Africa, South America Emergency hospital during 1918 influenza epidemic, Camp Funston, Kansas Copyright © 2006 Dr. Salme Taagepera, http://www.vaccineinformation.org/photos/flu_afp001a.jpg 11 Viruses are NOT: Plants Animals Bacteria Viruses ARE parasites Viruses cannot function or reproduce without a host cell Viruses CANNOT: Synthesize proteins Generate or store energy (ATP) Synthesize building blocks (amino acids, nucleotide, lipids) Viruses CAN: Reproduce prolifically in a host cell http://micro.magnet.fsu.edu/cells/virus.html What are viruses? Copyright © 2006 Dr. Salme Taagepera, 12 Viral life cycle
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13 14 Question 1 Please write down your SID# and speculation 15 Influenza (flu) virus anatomy 1. Nucleic acid: RNA in 8 segments 2. Protein capsid 3. Envelope contains glycoprotein spikes: Hemagglutinin (80%) = functions to attach virus to host cell Neuraminidase (20%) = facilitates release of virus from host cell 1. 2.
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This note was uploaded on 04/24/2008 for the course BIOL 12d taught by Professor Whiteson during the Winter '08 term at UC Irvine.

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lecture12flu+ - Bio 12D Lecture 11 I. Infectious Disease...

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