Lecture16stemcells - Bio 12D Lecture 16 PEDIATRICS Volume...

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Bio 12D Lecture 16 I. Stem Cells and cloning Week 10 Reading Scientific American Stem Cell Guide Final Thur 3/20 1:30-3:30 HSLH 200 (right here) ***Review Thur 3/13*** evaluation 2 extra credit points Review thimerosal Mercury ABSTRACT OBJECTIVES . Thimerosal is a mercurial preservative that was widely used in multidose vaccine vials in the United States and Europe until 2001 and continues to be used in many countries throughout the world. We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines. METHODS . Blood, stool, and urine samples were obtained before vaccination and 12 hours to 30 days after vaccination from 216 healthy children: 72 newborns (group 1), 72 infants aged 2 months (group 2), and 72 infants aged 6 months (group 3). Total mercury levels were measured by atomic absorption. Blood mercury pharmacokinetics were calculated by pooling the data on the group and were based on a 1-compartment first-order pharmacokinetics model. RESULTS . For groups 1, 2, and 3, respectively, (1) mean SD weights were 3.4 0.4, 5.1 0.6, and 7.7 1.1 kg; (2) maximal mean SD blood mercury levels were 5.0 1.3, 3.6 1.5, and 2.8 0.9 ng/mL occurring at 0.5 to 1 day after vaccination; (3) maximal mean SD stool mercury levels were 19.1 11.8, 37.0 27.4, and 44.3 23.9 ng/g occurring on day 5 after vaccination for all groups; and (4) urine mercury levels were mostly nondetectable. The blood mercury half-life was calculated to be 3.7 days and returned to prevaccination levels by day 30. CONCLUSIONS . The blood half-life of intramuscular ethyl mercury from thimerosal in vaccines in infants is substantially shorter than that of oral methyl mercury in adults. Increased mercury levels were detected in stools after vaccination, suggesting that the gastrointestinal tract is involved in ethyl mercury elimination. Because of the differing pharmacokinetics of ethyl and methyl
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This note was uploaded on 04/24/2008 for the course BIOL 12d taught by Professor Whiteson during the Winter '08 term at UC Irvine.

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Lecture16stemcells - Bio 12D Lecture 16 PEDIATRICS Volume...

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