This preview shows page 1. Sign up to view the full content.
Unformatted text preview: phase. Why DES? Key: reduce restenosis (renarrowing). Design Considerations of DES Flexibility, size, biocompatibility, releasing effectiveness, coating Stent Materials Bare stents are made of stainless steel. Could be made of inorganic materials or polymers, alloys, etc. Or, bare stents + other materials as coating. Stent Manufacturing procedures 1. Flat pattern 2. Cut hollow slots 3. Stretch and Deform, touch 4. Connect 5. Polish, sterilize Releasing Methods of the drug 1. Combine Stent and Drug (bad?) 2. Combine with outside Coating (classic) 3. Additional Catheter Delivery (Good, but invasive) Coating of the stents An example: Thin film is made by N-O reaction in vaccum tube; thickness is 500nm ; Evaluations: 1. PES vs SES 2. Bare Stents Vs. DES 3. DES vs. Bypass Surgery Future works 1. Reduce Hypersensitivity 2. Better drug delivery, less platelet 3. Dual antiplatelet therapy 4. Biodegradable materials...
View Full Document
- Fall '07