Drug_eluting_stents_summary - phase Why DES Key reduce...

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Drug-eluting Stent Group9 Yifan Zhang Rui Zhu Rohan Desai Coronary Artery Disease (CAD) Surgery options : 1. Bypass surgery 2. Coronary angioplasty plus stent Stent materials: Stainless steel, Gold, Tantalum, Nitinol (shape-memory nickel-titanium alloy), Polymer materials Disadvantage of bare stents: 1. Provoke inflammation and clot formation. 2. Tissue proliferation Drug-eluting stents (DES): DES is a stent with a drug-eluting coating. The drug used in the coating can be released gradually for the long time, and it can prevent the restenosis of the plaque over the stent. Drugs used in DES: 1. Sirolimus (rapamycin) It has potent immunosuppressive and antiproliferative properties – inhibiting the translation of key mRNAs of proteins required for cell cycle progression from G1 to S phase. 2. Paclitaxel it hyper-stabilize the structure of microtubule, which destroys the cell’s ability to use its cytoskeleton in a flexible manner. So, it inhibits cellular replication in the G0/G1 and G1/M
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Unformatted text preview: phase. Why DES? Key: reduce restenosis (renarrowing). Design Considerations of DES Flexibility, size, biocompatibility, releasing effectiveness, coating Stent Materials Bare stents are made of stainless steel. Could be made of inorganic materials or polymers, alloys, etc. Or, bare stents + other materials as coating. Stent Manufacturing procedures 1. Flat pattern 2. Cut hollow slots 3. Stretch and Deform, touch 4. Connect 5. Polish, sterilize Releasing Methods of the drug 1. Combine Stent and Drug (bad?) 2. Combine with outside Coating (classic) 3. Additional Catheter Delivery (Good, but invasive) Coating of the stents An example: Thin film is made by N-O reaction in vaccum tube; thickness is 500nm ; Evaluations: 1. PES vs SES 2. Bare Stents Vs. DES 3. DES vs. Bypass Surgery Future works 1. Reduce Hypersensitivity 2. Better drug delivery, less platelet 3. Dual antiplatelet therapy 4. Biodegradable materials...
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