Drug_eluting_stents

Drug_eluting_stents - Drug-eluting Stent Group 9 Yifan...

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Drug-eluting Stent Group 9    Yifan Zhang Rui Zhu Rohan Desai (DEN)
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Background: Coronary Artery Disease (CAD) What is CAD? Plaque build up Narrowing of the arteries that supply nutrients and O 2 to heart about 16 million Americans (2004) Half a million die every year Symptoms Chest Pain Heart Attack Death Risk Factors High Blood Pressure High cholesterol and triglycerides Diabetes Obesity Smoking Lack of physical activity Family history Diagnosis ECG or EKG Stress Test Coronary Angiogram Treatment Options Life style change Medication Invasive methods Source:http://www.nlm.nih.gov/medlineplus/ency/imagepages/8755.htm
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Background: Invasive Methods to Treat CAD 1. Bypass Surgery. Arteries or veins from elsewhere in the patient's body are grafted to the coronary arteries to bypass atherosclerotic narrowings and improve the blood supply to the coronary circulation supplying the myocardium (heart muscle) . 2. Coronary Angioplasty , Angioplasty involves temporarily inserting and expanding a tiny balloon at the site of the blockage to help widen a narrowed artery. Angioplasty is usually combined with implantation of a small metal coil called a stent in the clogged artery to help prop it open and decrease the chance of it narrowing again (restenosis). Coronary Stent System http://www.intek.ch/drug.html Bypass Surgery
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Stent Placement Source: http://www.nhlbi.nih.gov/health/dci/ diseases/angioplasty/angioplasty_whatis.ht ml
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Disadvantage of Bare Stents 1. Stents cause damage to the vessel wall, and, as foreign objects, they provoke inflammation and clot formation. 2. Tissue proliferation in the stent can cause the vessel to narrow again. 3. Patients with stents must remain on antiplatelet drugs. e.g. clopidogrel for at least three to six months; discontinuing it, even for a short time, can cause a clot to form; aspirin must be taken for life.
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Drug-Eluting Stents (DES)
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What Drug? (1) Sirolimus Sirolimus (rapamycin) is a macrocyclic lactone antibiotic. The first successful trials of the DES were of
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Drug_eluting_stents - Drug-eluting Stent Group 9 Yifan...

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