Cardiac_Progenitor

Cardiac_Progenitor - Tissue Engineering Cardiac Progenitor...

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Tissue Engineering: Cardiac Progenitor Cells A. Cyrus Arman Anna A. Zhu December 3, 2008
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What is Tissue Engineering? • Progenitor Cells (Stems Cells) – Pluripotent • endoderm (stomach lining, GI tract, lungs) • mesoderm (muscle, bone, blood, urogenital) • ectoderm (epidermal tissues and nervous system) – Divide asymmetrically (self-renewing) • Organs and tissues fail with time • Progenitor Cells can repair defunct tissue
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Candidate Progenitor Cell Types Adapted from Dimmeler et al. 2005
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Clinical Therapies Autografts (Autologous) - harvesting tissue from a patient’s own body for transplanting into the same patient – bone, ligaments, blood vessels, etc. – (+) good clinical outcomes, little rejection – (-) harvest sites limited, expensive, pain, infection, 2 wound sites Allografts (Allogeneic) – harvesting tissue from a deceased or living donor, transplant to a patient – heart, kidneys, lungs, liver, bone marrow, tendons, ligaments, cartilage, cornea, blood vessels – (+) can be a good match – (-) anti-rejection drugs required, shortage of donor tissues/organs
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Cardiac_Progenitor - Tissue Engineering Cardiac Progenitor...

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