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Unformatted text preview: 1 BME 501 FINAL EXAM STUDY GUIDE 12/07 1. Chapter 1 Blood Flow Name the 5 different types of leukocytes and their specific role(s). Which one is most abundant in the circulation? Which one is responsible for the humoral response in organ rejection? What are the cells involved in rejecting implantable device? What are the cells involved in rejecting stem cell transplant? Our California governor is taking Warfarin (Coumadin) to prevent hemostasis II for his aortic mechanical valve. If Arnold received an Edward Science pericardial valve, is chronic anticoagulation therapy indicated? During CABG (cardiac aortic bypass graft) surgery, the patient is put on the heart lung by-pass machine, why is anticoagulation indicated? How is the perfusionist monitor whether the dosage is within the therapeutic range? In equation 2, describe the individual terms. For Newtonian fluid at a constant density, viscosity, and at steady state, what terms are cancelled? Derive Womersley’s and Reynolds numbers. Hemostasis • Following injury to a blood vessel, all of the systems are activated. • The hemostatic process is divided into 2 components; – primary hemostasis • Primary hemostasis depends upon the response of the platelet and blood vessel wall to the injury. When the small blood vessels are injured, blood platelets adhere and aggregate at the site of injury, reducing and finally arresting bleeding. – secondary hemostasis • Secondary hemostasis starts when the cascade system of coagulation is activated by substances released at the time of blood vessel injury. Clinical application: PT • The Prothrombin Time or PT is a laboratory screening test used to detect coagulation disorders. It measures the activity of the factors of the extrinsic pathway including factors II, V, VII, X, and fibrinogen. The extrinsic factors not measured in the PT test are Factors III (Thromboplastin), and IV (Calcium). • The PT is also used to monitor oral anticoagulant therapy such as warfarin. Navier-Stokes Equations 3-D unsteady flow where u = velocity vector field, = thermodynamic internal energy , p = pressure, T = temperature, = density, = viscosity, KH = heat conduction coefficient, F = external force per unit mass, and 2 If the Womersley’s number is zero and Reynolds’ number is less than 500, draw the velocity profile in a 2-D channel. If the Womersley’s number is 11 and Reynolds’ number is less than 500, draw the velocity profiles in one cardiac cycle. What is the range of Reynolds number for capillary surrounding alveolar sacs? What is the range of Reynolds number for blood flow across the aortic valve? Chapter 4 Name two commonly used by-pass grafts. The valves in the vein grafts affect blood flow, how is the surgeon anastomose the vein graft to bypass the coronary artery with atherosclerosis....
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This note was uploaded on 02/27/2008 for the course BME 501 taught by Professor Yamashiro,hsiai during the Fall '07 term at USC.
- Fall '07